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KMID : 0613820070170070923
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Journal of Life Science
2007 Volume.17 No. 7 p.923 ~ p.930
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Wnt7b is Upregulated in Macrophages during Thymic Regeneration and Negatively Regulated by RANKL
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Kim Jong-Gab
Kim Sung-Min
Kim Bong-Seon
Kim Jae-Bong
Yoon Sik
Bae Soo-Kyung
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Abstract
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Thymus can regenerate to its normal mass within 14 days after acute involution induced by cyclophosphamide (CY) in adult rat. Despite the established role of Wnt pathways in the process of thymus development, they have not yet been associated with the regeneration of adult thymus. The purpose of this study was to investigate whether Wnt7b, which is expressed in developing thymic epithelial cells rather than in thymocytes, is modulated during thymic regeneration in adult rat. Here, we show that Wnt7b expression was up-regulated in the regenerating thymus. Cells immunolabeled for the Wnt7b were identified as macrophages. Furthermore, Wnt7b gene expression was decreased by the treatment of receptor activator of NF-kappaB ligand (RANKL). Taken together, our results demonstrate that Wnt7b gene expression was increased in macrophages during thymic regeneration and negatively regulated by RANKL.
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KEYWORD
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Wnt7b, RANKL, Thymus, Regeneration, Macrophage
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